ClearogenPro E-learning for Skin Experts

A Comprehensive Guide for Clearogen Skin Experts 

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Medical Presentation


AMCSA Medical Presentation - Dr Marianne Duvenage



Table of Contents:


1.1 What is congestion in the skin?

1.2 Primary causes of congestion in the skin

1.3 How to prevent congestion from forming

1.4 Medical treatment options for congested skin prone to Acne

1.5 Aesthetic & OTC options available for treatment of congested skin prone to Acne

1.6 Side effects of conventional treatment for congested skin prone to Acne

1.7 The essential difference between male and female Acne

1.8 Facial Diagnostic Tool 

1.9 Extractions for Acne-Prone Skin 

1.10 Knowledge Assessment


2.1 The Dr & Research behind the brand

2.2 What makes Clearogen unique?

2.3 Ingredient selection and formulation

2.4 Who should use Clearogen?

2.5 When should use be discontinued?

2.6 User Guide (Table)

2.7 Competitor Analysis

2.8 Helpful to know

2.9 Troubleshooting

2.10 Knowledge Assessment



Great! That's all you need to know, now you are ready to rock their world :) 






Introduction : The Skin


The skin consists of three distinct layers, namely the;

The word “derma” is an ancient Greek word meaning ‘skin’.  Both the epidermis and dermis are named after this word, and for this reason, a medical practitioner specialising in skin diseases and conditions is called a dermatologist. The activities linked to Acne are occur in the Dermis, where the sebaceous glands are connected to hair follicles. The evidence of these activities are seen on the surface of the skin as Acne. 

3 Main Layers of the Skin:

1.1 What is congestion in the skin?

Congestion is an accumulation of waste matter in the pores or follicles of the skin.  Waste matter in the skin consists mainly of skin oil, known as sebum and perspiration produced by sudoriferous glands (sweat glands) that mixes with dead skin cells called keratinised cells or corneocytes.  Congestion can lead to inflamed conditions such as Acne or non-inflamed conditions on the skin such as Milia (Milk Spots) or Comedones (blackheads) .  Where inflammation is present the skin will present red, raise bumps and often this leads to infection as micro-organisms go to work trying to clean the skin by metabolising the oil and debris in the skin. Unfortunately, very often this bacterial activity triggers an immune response , visible as pustules, cysts and other Acne lesions on the surface of the skin. The presence of pus indicates infection. 

The life cycle of a skin cell is an average of 28 days, after which it is shed and replaced by a newer cell. The journey starts  in the Basal Cell Layer (Stratum Germinativum), where the cell is initially plump and round. Soon the cell flattens and hardens as it moves towards the surface of the skin to form the Stratum Corneum. The surface of the skin is irregular and has hills and valleys, as can be seen in the skin diagram below. 

1.2  Primary causes of congestion in the skin

The Hormone DHT

The #1 cause of congestion in the skin is excess oil (sebum) produced by the sebaceous gland attached to the hair follicle. Sebum is made of cholesterol, free fatty acids, glycerides, squalene, and wax esters. The hormone DHT causes the excess production of sebum and triggers a cascade of events which leads to congestion in the skin and  often progresses to Acne.  DHT is produced when the androgen based enzyme 5aR ( 5-alpha reductase) interacts with, the hormone testosterone , which is produced at the site of the sebaceous gland.  

When the androgen hormone DHT attaches to the sebaceous gland receptors, it results in the stimulation of the oil secretion, which mixes with debris and a sebaceous plug is formed. If the pore remains open on the surface of the skin,  the top layer of the plug darkens through oxidation and a blackhead is formed. If the plug is situated lower down the opening of the skin and if the mouth of the opening is closed by dead skin cells, this may lead to the formation of a sebaceous cyst,  pustule ( commonly called a pimple) or other infected skin lesions otherwise classified as Acne. 

Nutrition and Lifestyle Choices

Nutrition & Lifestyle choices may also influence the condition of the skin. Our bodies extract vitamins, nutrients and water from the food we eat. Certain food sources and supplements contain adrenal stimulants, which activate the adrenal function of the body, thereby releasing adrenaline.  

In response the Pituitary gland produces a hormone called Cortisol.  Cortisol is also called the "Stress Hormone" since it is produced when the body responds to the "fight or flight" hormone, adrenaline.  

The primary purpose of Cortisol for:

  • Anti-inflammatory actions
  • Bood-sugar (glucose) levels
  • Fat, protein and carbohydrate metabolism to maintain blood glucose (gluconeogenesis)
  • Immune responses
  • Blood pressure
  • Heart and blood vessel tone and contraction
  • Central nervous system activation

Effects of prolonged exposure to Cortisol:

  • Impaired cognitive performance
  • Dampened thyroid function
  • Blood sugar imbalances, such as hyperglycemia
  • Decreased bone density
  • Sleep disruption
  • Decreased muscle mass
  • Elevated blood pressure
  • Lowered immune function
  • Slow wound healing
  • Increased abdominal fat, which has a stronger correlation to certain health problems than fat deposited in other areas of the body. Some of the health problems associated with increased stomach fat are heart attacks, strokes, higher levels of “bad” cholesterol (LDL) and lower levels of “good” cholesterol (HDL), which can lead to other health problems.    

Certain Food sources and supplements contain sugar in its various forms ( these are usually recognisable as ingredients ending in "ose" such as sucrose, glucose dextrose, lactose and fructose to name a few). Various sugars stimulate the pancreas which increases insulin production and recent studies indicate that insulin may also cause a cascade of events which can bring about Acne.  

Comedogenic Ingredients

Congestion may also be aggravated by cosmetics which contain ingredients that are not metabolised or absorbed by the skin (These are called comedogenic ingredients). Substances can become trapped in the skin and are visible as non-inflamed bumps, which eventually become expelled through the surface of the skin and may become inflamed or infected as the skin's natural regeneration process takes place.

1.3 How to prevent congestion from forming

Avoid Skin Aggravating Habits

  • Don't scratch! Nails and hands are breeding ground for bacteria.
  • Avoid abrasive facial exfoliants (Granular scrub or Mechanical Facial Brushes) 
  • Smoking deprives the skin of oxygen levels and may weaken the skin's immune system
  • Drinking excessive volumes of alcohol puts stress on internal systems
    • Alcohol may also cause dehydration and broken capillaries on the skin.
  • Over-Exercise may lead to side effects due to prolonged exposure to adrenaline and cortisol
  • Taking chemical performance enhancers which disrupt the hormonal (endocrine) system

Eat Well & Hydrate

Knowledge Basket: Read more about foods to avoid Click Here

  • Eat the rainbow in fresh fruit and vegetables to get all the vitamins and minerals
  • Avoid excessive intake of animal fats, dairy and stimulants (caffeinated beverages) 
  • Eliminate all artificial additives and preservatives 
  • Avoid kelp and iodine
  • Take Supplements!

  • Zinc

    Zinc is widely known to boost the skin's immune system and is a key supplement to support skin prone to Acne. This mineral supports cell growth and regeneration, therefore, it is used to treat skin conditions, including Acne.

    Increasing dietary intake of zinc may prove beneficial to the skin. Many foods contain zinc including oysters, lean red meat, lima beans, chickpeas, sesame seeds, pumpkin seeds, and even chocolate.  It is also possible to increase your zinc intake by using galvanized cookware.

    NB Chocolate does not cause acne, but sugar and certain fats could, the cocoa however may even have some benefit for the skin, so the darker the better. 

    Zinc supplements may be beneficial in healing Acne. Acne treatment doses are usually between 45mg and 60mg daily or more. Be careful of taking high doses of zinc long term because zinc toxicity is dangerous.
  • Vitamin A

    Derivatives of vitamin A called retinoids are used to treat Acne and other skin disorders. The retinoids tretinoin (Retin-A) and isotretinoin (accutane) are often prescribed to treat Acne. These medications may have strong side effects so they should be taken with caution and only under a doctor’s supervision.

    Isotretinoin should only be used for severe Acne that is resistant to other treatments and should never be used by women who are pregnant or those planning a pregnancy,  because of the risk of severe birth defects.

    Vitamin A supplements may also reduce Acne in some people, but it is best to get vitamin A through food sources including fish, dark colored fruits and vegetables (specifically beta-carotene found in carrots) - other sources include pineapple, and dairy products, provided you are not lactose intolerant. Also, just a word of caution, excessive consumption of dairy products have been proven lead to an increase in congested skin. This has to do with the natural growth hormones found in milk (intended for cow to help them grow) and a few other facts you can read about here. 
  • Vitamin C

    As a supplement, vitamin C (ascorbic acid) has anti-oxidant properties and helps with wound healing as well as boosting the immune system, which in turn helps to prevent and heal Acne lesions. Most fruits and vegetables are sources of vitamin C of which the highest values are found in papaya, raw red bell pepper, strawberries, oranges, broccoli, cantaloupe, lemon juice, kiwi, cauliflower, and kale.

    When applied topically, vitamin C serum assists with collagen regeneration, by stimulating the fibroblast cells where the collagen is produced.  Not only is this an excellent age prevention step, but it also assists with healing blemishes which often remain for long periods of time after a breakout or skin eruption.

  • ​4. Vitamin E 

    Another antioxidant, vitamin E, is  one of the best vitamins for Acne prevention. Vitamin E has been called the “beauty vitamin” because of its ability to regulate retinol levels for skin health as well as protect skin from ageing caused by oxidative stress. Oxidative stress is one of the main underlying causes of Acne. Vitamin E is an important vitamin for preventing and healing Acne and used topically it greatly assists with tissue healing.

    Some vitamin E rich food sources include mustard greens, chard, sunflower seeds, turnip greens, almonds, spinach, papaya, and blueberries. When taking vitamin E in supplement form be sure it is food-sourced and not petroleum based. Vitamin E gel caps are good because the oil inside can be used topically for healing the skin. Snip or puncture the gel cap and squeeze some of the oil out onto your clean fingers and apply to spots before bed.
  • 5. Selenium 

    Selenium is an essential mineral, present in the body in trace amounts. Selenium deficiency is believed to be the source of the problem some cases of Acne. It works in combination with vitamin E to reduce inflammation and boost the body’s immune system. Selenium is also thought to support thyroid function which means it may be beneficial in controlling hormone related Acne.

    Most people get enough selenium in their diet, but there are instances where  selenium deficiency may occur due to health and lifestyle choices. This includes; smoking, taking certain medications such as oral contraceptives and the effects of certain diseases or conditions that cause poor mineral absorption may also result in selenium deficiency. Dietary sources of selenium include nuts, cereals, meat, mushrooms, fish, and eggs, tuna, crab, and lobster.
  • 6. Essential Fatty Acids, Specifically Omega-3

    Essential Fatty Acids accelerate healing in the body and have anti-inflammatory effects

    Essential fatty acids are the main structural components of the body's cell membranes, therefore, a balanced intake of fatty acids is necessary for healthy cell function. Our entire system functions on the basis of an osmotic interchange between cells and healthy cell membranes allow a greater flow of nutrients in and toxins out.

    The cell is like a tiny factory, taking in raw materials from the surrounding fluid and sending out various chemicals. Everything going into or coming our of the cell has to pass through the cell's outer surface - its membrane. The membrane depends on essential fatty acids to remain fluid and flexible. Without them, the membrane becomes stiff and unable to do its job. 

    There are numerous health problems associated with EFA deficiencies. These include hair loss, eczema, skin eruptions, susceptibility to infections, arthritic conditions, liver or kidney degeneration, growth retardation and vision or learning problems. Positive health effects of the essential fatty acids include anti-oxidant activity, cardiovascular protection, maintenance of healthy skin, anti-microbial activity and tumor inhibition

    Omega-3 is one such a fatty acid, which offers great value in supporting Acne-prone skin. There is strong evidence that diets high in dietary omega-3 fatty acids can reduce or eliminate Acne flare-ups due to its anti-inflammatory properties in the body while omega-6 fatty acids produce inflammatory chemicals in the body. The ratio of omega-6 to omega-3 fats is important. For optimal health, the ratio should be no greater than 4:1, and some nutritionists prefer 2:1. The standard American diet is closer to 10:1. So for preventing and healing Acne (and heart health), eat more foods rich in omega-3s like flaxseed oil, canola oil, walnuts, olives, wild salmon, tuna and sardines and eat fewer foods rich in omega-6 fats like safflower oil, corn oil, peanut oil, butter, and meat.  
  • 7. Magnesium 

    Magnesium  is associated with reducing inflammation and since inflammation is one of the main causes of acne, it helps a great deal. Magnesium also plays a role in hormone balance, another contributor to Acne. Magnesium absorption may be reduced when taking zinc supplements, but it is absorbed better when taken with vitamin C. This is why magnesium citrate is a common magnesium supplement. Foods rich in magnesium are dark leafy greens, summer squash, broccoli, blackstrap molasses, halibut, pumpkin seeds and peppermint.

    Vitamins and minerals play a fundamental role in controlling Acne and understanding the minerals and vitamins for Acne prevention is important for your skin care regimen.

    If you suspect that a vitamin or mineral deficiency is at the source of the Acne, then increase the intake of foods rich in that nutrient to the diet. Taking supplements under the guidance of a medical practitioner or nutritionist may offer excellent support for Acne-prone skin, with lasting results. 

  • Be sure to drink optimal levels of fluids daily . Hydration Calculator

Look after your Adrenal System 

  • Get sufficient rest - the body performs vital regenerative functions during sleep cycles. 
  • Moderate daily exercise is an excellent stress reliever 
  • Avoid taking Stimulants and Chemical Enhancement Supplements
  • Make time to relax and breathe - heightened stress induces shallow breathing 

Research the Properties of Cosmetic Ingredients

Harsh chemical products strip the skin of moisture, causing sensitivity and often upset the natural pH balance of the skin (acid mantle). 

Use the INCI search directory to verify the properties of any ingredient in your product of choice :
e.g. Click on the INCI search directory, type the word "wheat" (without the inverted commas) and click on the term "hydrolised wheat protein". The directory gives a full explanation of the properties of that particular ingredient. 

Or search EWG's Cosmetic Database

Use Intelligent Skincare

Gone are the days of cleanse, tone, moisturise. We have greater expectations and we should. Let's take a look at the properties that Acne-prone users should look for in a skincare range:

Some examples of preferred ingredients for Acne-prone skin types are:

Look for Ingredients with exfoliating and anti-inflammatory properties, specifically ingredients which do not cause sensitivity on the skin. Harsh, sensitising ingredients are counter productive for Acne-prone skin types, since this would cause further inflammation in the skin.  


Look for ingredients that support the function of the cleanser and the overall objective of dissolving redundant skin cells and pore clogging matter.  The toner should be medicated and may repeat the use of ingredients contained in the cleanser to enhance results. Caution should be used when applying a medicated toner i.e. avoid sensitive or dry areas. It may be a good idea to apply to problem areas only and start slowly, by applying only once per day during the first week to introduce the active ingredients to the skin. Gradually increase dosage and then decrease again to maintain. 


Acne-prone skin should opt for light lotions and creams,which still offer all the nourishment and moisture properties of a regular cream, without the side effect of clogging pores. Depriving oily or problem skin of moisture will only aggravate the condition, as the skin as cells need moisture to exchange nutrients and perform general cellular interactions.  In addition, a dehydrated (lacking water) skin will be inclined to over produce sebum in an attempt to make up for the shortfall. However, sebum only lubricates the skin and does not put water into the skin. Our skin can become dehydrated for a number of reasons including, outdoor living, climate control, medication, lifestyle choices and general health. 

A suitable daily lotion must be applied day and night until the problem skin is cleared. Following this,  the skin should be analysed once again to assess which maintenance cream to use. Naturally, the best daily lotion should contain anti-bacterial and healing properties. Additional medicated ingredients which control hormonal processes in the skin would offer a winning solution. An example of such an ingredient is Saw Palmetto, which contains Beta-sitosterol. This key ingredient inhibits the 5aR Enzyme, responsible for destructive DHT processes. 

Other skin conditions such as ageing or pigmentation should be dealt with as a secondary objective. In other words, first get the skin's immune system to a healthy state by reducing inflammation in the skin, which will give a sound foundation for addressing other skin conditions more successfully.

Knowledge basket: Pigmentation Disorders and Ageing have something in common with Acne - they are all associated with inflammation to start with. Use anti-oxidant rich supplements and skincare to form a healthy platform for future skincare programs. 


Choose a water based sunscreen of SPF 15 or higher. When blemishes come into contact with UV light, they darken due to melanin in the skin and the over production of melanin the a site injury in the skin. The spots that appear during and after a breakout are classified as blemishes. In addition, over exposure to the sun causes sebaceous oil to thicken, resulting in an apparent clearing of the skin, only to surface as a breakout a few days later. 

The best SPF for Acne-prone Skin (or any skin in our opinion) must:

  • Be water based
  • Contain either or both Zinc Oxide and Titanium Dioxide.
    • Zinc Oxide protects from the full spectrum of UVA and UVB rays, very effectively, making it truly the best mineral sunscreen ingredient available. Zinc Oxide is also known to reduce bacterial growth and aid wound healing - ideal for Acne-prone skin!
    • Titanium Dioxide - Also a mineral similar to Zinc Oxide, however, recent studies have indicated the possibility that Titanium Dioxide can cause the release of Free Radicals when exposed to light.
    • Free Radicals damage cellular DNA, so if in doubt opt for an SPF with Zinc Oxide as the key ingredient.

Here are some of our recommended SPF Choices: 
Lucasunpeak , Eucerin and Bioderma

Knowledge basket: You should never rub sunscreen into the skin. Apply in a patting motion or you will hamper the efficacy of the sunscreen.  Avoid using chemical sunscreens as some of the ingredients found in chemical sunscreens have been proven to cause hormone changes and disrupt the natural functions of the skin, sometimes causing severe allergic reactions.

Always divide the SPF by 10 to determine a guideline for how long the SPF might offer protection. E.g. SPF 30 = 3 hours, SPF 50 = 5 hours and so forth.

The Fitzpatrick Scale helps to categorise skin sensitivity to the sun:


Frequently asked questions during Consultation

Q1: I do not feel clean unless I use soap on my face.  Some people have told me to use soap and water and others say that soap should never be used on the face.  What is the answer?

A: The Skin has a delicate pH balance. You can learn more about the pH balance of the skin from your Clearogen Skin Expert. To put it simply, the pH Level of the skin is a scale used to measure the natural acid-alkaline balance of the skin. If the skin is too acidic it has a high pH balance and will show signs of dryness, flakiness and may even be prone to eczema.  Never use soap on the face as soap is too alkaline, which means that it will strip the skin of its natural lubrication called the acid mantle and the skin will then be prone to infections.  Rather use a professionally formulated cleanser on the face, which will cleanse the skin without disturbing the delicate ecosystem of the skin. On the flip side, if your skin is oily, the pH is too low and your skin is acid. Bacteria thrive in an acid pH and this may also result in skin problems.

Q2: Why is it necessary to use a Toner after cleansing the skin?

A: Traditionally, it is essential to tone the skin after cleansing as it removes excess cleanser from the skin, helps to balance the skin’s pH and acts as an extra cleansing measure. Not all toners are created equal, for example, an active toner like the Clearogen Step 2 Toner will also remove dead skin cells, thereby reducing visibility of pores, while acting as an antibacterial treatment to reduce the likelihood of breakouts on the skin. Although some flaking may be experienced with an active toner, this is a desired result and usage can be adjusted for even the most sensitive skin type. When using an active toner, the frequency of use must be adjusted.

Q3: My skin is flaky.  Does this mean I need to apply moisturiser or oil to compensate?

A: When the skin is dry, it can be oil dry (lacking nutrients and natural oils) or moisture (water) dry.  When deprived of water we call the skin dehydrated, when deprived of oil, we call the skin dry. An imbalance in the nature oil and water content of the skin will compromise the immune system of the skin and make it more prone to bacterial invasion. Oil will not replenish moisture in the skin but it will provide a protective film to keep moisture from evaporating from the skin.  It is best to use an emulsion formulated for your skin type

Q4: My skin is oily, does this mean I need to use a moisturizer?

A: Oily skin can be dehydrated especially due to health or environmental conditions.  Oily skin may have dry areas such as around the eyes.  Under these conditions, a moisturizer is beneficial.  Even an oily skin needs moisture for age prevention. Many people who have oily skin prefer to skip the moisturising cream in fear of increasing the greasiness of the skin or causing congestion (breakouts). The truth is that if you do not moisturise and oily skin with a light cream, the skin will overcompensate by manufacturing more oil to lubricate the skin. The best advice for oily skin is to use a light textured moisturiser with botanic ingredients to stop the excessive production of sebum (skin oil). The right anti-blemish daily lotion will add moisture (water) to the skin, while reducing the activity of the sebaceous (oil) glands in the skin. An example of such a cream is the anti-blemish day cream of Clearogen.

What is Clearogen?

A three-step, non-invasive skincare product that uses botanic ingredients to  the acne inhibit the Acne-causing hormone DHT. 

 1.4 Medical treatment options for congested skin prone to Acne


(Tazarac, RetinA, & Differin all in the same family)


Exfoliates and increases cell turnover on the surface of the skin to open pores, keep them open, and ease extraction of blackheads and whiteheads. Highest strength exfoliator.

Effective in treating the symptoms of problem skin through removal of dead skin cells.

Irritation, redness, sensitivity and itching at beginning of use.
Cannot be used on even moderately sensitive skin.
Does not target the source of problem skin (The Hormone DHT)

Retin-A/ Retin- A Micro

Exfoliates and increases cell turnover on the surface of the skin to open pores, keeps them open, and allows for easy extraction of blackheads and whiteheads. Medium strength exfoliator.

Effective in treating the symptoms of problem skin through removal of dead skin cells.

Possible Side Effects - Irritation, redness, itching and sensitivity.
Can't be used on sensitive skin.
Does not target the source of problem skin (The Hormone DHT)

Differin Gel or Cream

Exfoliates and increases cell turnover on the surface of the skin to open pores, keep them open, and easy extraction of blackheads and whiteheads. Mild prescription exfoliator.

Effective at exfoliating skin and preventing clogged pores.


Does not kill bacteria
Does not block DHT
Does not regulate oil production.
Possible side effects: Irritation, redness, itching, sensitivity.

Accutane/ Oral Isotretinoin

Synthetic vitamin A, taken orally it shrinks the sebaceous glands in the face but also throughout the entire body.

Very Effective for cystic acne.

Side effects include depression, thoughts of suicide, dry, itchy skin, hair loss, permanent decrease in sebaceous gland size which can lead to decreased oil production throughout the entire body. Taken off market in 2007 due to lawsuits.

Birth Control


Increases female hormones Oestrogen and Progesterone which block DHT.

Very Effective 

Emotional side effects, possible weight gain, increases risk for heart attack, stroke and blood clots, cannot be taken by Men.

Oral Antibiotics

Kills bacteria throughout the body and on the skin.

Very Effective, only known effective method for advanced cystic acne. 

Kills all bacteria, immune system eventually builds up a resistance to the antibiotics making them less effective for use against illnesses. Side effects include nausea & headaches.


1.5 Aesthetic & OTC options for treatment of congested skin prone to Acne

Most Cosmeceutic, Pharmacetic and OTC options rely on Exfoliating Enzymes, Acids and Chemicals to remove the stratum corneum , additionally, they offer anti-bacterial and healing properties, but do not address the root cause of Acne-prone skin, namely, the formation of DHT.

Usually a minimum of 3, 6 or more products are required to achieve desired results, leading to tedious, expensive skincare routines that are not sustainable long term. Although effective in exfoliating the skin and to control bacteria in some extent, many of these options are accompanied by unpleasant side effects and a lack of long term results. This is the equivalent of taking medication for a recurring headache, but never addressing the source of the headache.

Aesthetic Support Options

A number of procedures are recommended to support Acne-prone skin:

Drainage and extraction is a procedure in which the Skincare Clinician or Practitioner  manually drains large cysts that form under the skin. They remove fluids and materials inside the cyst to reduce infection and pain. Medications such as corticosteroids may be injected into the cyst to speed healing and reduce the risk of scarring.

Laser therapy & Light Therapy Variations may also be helpful in controlling the activity of P. Acnes bacteria, thereby reducing infection. Laser procedures are proven to be effective in removing scarring in post Acne case studies. 

Resurfacing Skin Peels and Microdermabrasion, remove the top layer of the skin and in the process, are superficial blemishes are also removed.

These treatments are somewhat uncomfortable, but often necessary to refine the skin and reduce scarring, however, performing stimulating treatments such as Microdermabrasion or Resurfacing Skin Peels, it is not recommended during an active breakout. In cystic cases or active breakouts, these treatments may cause the site of infection to spread.

Additionally, the skin may interpret these treatments as trauma or injury, so every care must be taken to keep inflammation under control when performing these procedures on an Acne-prone skin, since this could trigger a breakout due to underlying congestion. 

If carelessly performed, these treatments may result in permanent scarring and medical insurance does not always cover them either. Use the services of trained professionals to avoid costly mistakes and life-long scaring. 

1.6 Side effects of conventional treatment 


Possible side effects which may occur:

  • pH Disturbances 
  • Anaphylactic Shock
  • Redness & Sensitivity
  • Itching  & Severe Flaking
  • Sun Sensitivity
  • Pigmentation
  • Oedema (Swelling)
  • Systemic absorption of chemical ingredients may lead to ill health.
  • Mutation of Skin Cells
  • Allergic Reactions due to:
    • Harsh chemicals
    • Unstable formulations
    • Unregulated concentrations of active ingredients
    • Pre-mature Ageing


Possible side effects which may occur:

  • Birth Defects
  • Infertility
  • Cancers
  • Photsensitivity 
    • Sun Sensitive
    • Sun Allergy
  • Anaphylactic Shock
  • Systemic Health Problems
  • Permanently damaging sebaceous function
  • Adverse effects on soft-tissue
  • Bone Density Issues
  • Co-morbid Depression
  • Pre-mature Ageing
  • Death

Mechanical (Resurfacing with chemicals or equipment)

Possible side effects which may occur:

  • Skin Eruptions
  • Adverse Skin Responses
    • Allergic reactions
    • Scarring
    • Pigmentation
  • Photosensitivity 
    • Sun Sensitivity
    • Sun Allergy
  • Inflammation
  • Infection

1.7 The Difference between Male and Female Acne



Nearly half of all adult women have Acne-Prone skin, for which a variety of treatments and prescriptions are available, with mixed results and often unwanted side-effects.

Androgen hormones surge, particularly during day 14 to 21 of the menstrual cycle and this may lead to breakouts in adult women with Acne-prone skin. It is interesting to note that along with estrogen, the ovaries produce small quantities of testosterone.


In the skin, the enzyme 5aR converts the testoterone into  another  androgen called DHT. (Dihydrotestosterone) 


Blemishes can occur before, during, or after menstruation, causing painful lesions along the jaw line, cheeks or chin. This is sometimes referred to as a hormonal breakout. Blemishes can occur anytime, causing painful lesions on the back, chest or face. 

Many women disclose that they never suffered from Blemishes in their teenage years, but, develop breakouts in their 30s or 40s for the first time.


This is can be attributed to hormonal changes in the female body during each cycle of their life and at times, due to starting or stopping birth control pills or other medications which influence hormone activity such as Menopause.

In addition to cellular and immune function, a careful analysis should be made of lifestyle factors such as stress, diet and exercise routines, as these may all influence the quality of the skin.

Polycystic Ovarian Syndrome or Polycystic Ovarian Disease

There is a high proportion of women who suffer from Blemishes during their menstrual cycle, while having menstrual cramping and bloating, along with Acne-prone skin, excessive hair loss on the scalp and/or excessive hair growth on the face and body (hirsuitism).  These women suffer from Polycystic Ovarian Syndrome or Disorder  (PCOS or PCOD.)


As the name implies, there are many cysts surrounding the ovaries that are responsible for abnormal androgen hormone production throughout the body. Standard treatment for this recommended by gynaecologists, include:

Birth control, spironolactone/Aldactone or cyperoterone acetate or Diane 35.


Clearogen is an additional PCOD Anti-Blemish support system due to the DHT inhibiting properties of the product.

Women with PCOD will greatly benefit from using Clearogen, as high DHT levels are responsible for the skin eruptions and breakouts.

Pregnancy & Acne-prone Skin

It should be noted that Clearogen contains Salicylic acid, an ingredient derived from fermented plant matter. 

The safety level of Salicylic acid in Clearogen has been approved by the FDA to be non-toxic and safe to use for both Maternal Females and their unborn fetuses. 

However, the skin should not be soaked in Salicylic solutions, as would be the case when performing a skin peel procedure. Systemic absorption may occur if the skin is drenched in Salicyic acid and high doses  in the bloodstream have been linked to birth defects. 

The primary cause of Acne-prone skin during pregnancy,  is the increased hormone levels in the first trimester.  Increased androgen levels in turn increase DHT levels and therefore the skin's production of natural oils.


Those who have a family history of Acne are genetically prone and at a higher risk of Acne-prone skin during pregnancy.  Similarly,  if the candidate has a history of acne or usually experiences breakouts at the start of her menstrual cycle, she is at risk.

Similar to their Female counterparts, nearly half of adult Men have Acne-prone skin, for which they too will use various anti-blemish solutions with mixed results such as, anti-androgen medications to lower testosterone levels.

Men using anabolic steroids, a testosterone-like substance, can also experience an increased tendency to breakout, due to higher levels of testosterone and therefore heightened DHT levels in the skin.


In Males, the hormone DHT  is also responsible for Acne-prone skin. Blemishes can occur anytime, causing painful lesions on the back, chest or face. 


The biggest difference between male and female skin is due to the male sex hormones known collectively as androgens. The main androgen at work in the male body is the testosterone group of sex hormones secreted by the testes.

Although there is variability, adult males produce about 10 times as much testosterone as women. Testosterone exerts its effects by acting on androgen receptors found throughout the body.


It does this directly, or by being converted into dihydrotestosterone (DHT), a much more potent activator of the androgen receptors.


Due to higher levels of androgens, Males have thicker skin and in addition testosterone yields a denser network of collagen and elastin  than in Female skin. The course terminal hair found on male skin also contributes to the overall increased density of male skin.

Hormonal control of the pilosebaceous unit (comprised of hair follicles and sebaceous glands) is the primary risk factor in developing Acne-prone skin.  

In addition to cellular and immune function, a careful analysis should be made of lifestyle factors such as stress, diet and exercise routines, as these may all influence the quality of the skin.


Males should avoid shaving over infected areas with blades and opt for an electric shave instead.

The Clearogen Cleanser offers an excellent shaving medium for guys prone to folliculitus and ingrown hairs. 


Men should avoid alcohol based aftershave lotions, as alcohol is known to cause dehydration in the skin, thereby thickening the production of sebum in the skin. 

















1.8 Facial Diagnostic & Survey

Analyse the Skin:

Unless there is some visible flaw, everyone's skin seems normal to them, but as any experienced skincare professional will tell you, a normal skin simply does not exist. Every skin type has concerns which need to be addressed. Even a so called “normal” skin without obvious concerns requires protection from ageing and sun damage (Photo damage). 

In order to care for diverse skin types, one needs to group the characteristics and appearance of the skin into specific categories. Determining your skin type is an important first step towards addressing your skins needs, regarding product selection and lifestyle choices.  Clearogen users may take the Clearogen Skin Survey to see where they can make adjustments. Our online Clearogen Skin Expert will get back to them with unique advice suited to their skin type. (The Survey is structured to help those with problem skin reflect on possible changes that can be implemented to improve the skin).

Step 1 - Cleanse the Skin

Wash with Clearogen Foaming Cleanser, removing all traces of make-up and pat dry. The cleanser removes oils and dirt that may have accumulated in the skin. Only cleanse twice per day. Over cleansing may aggravate skin problems and cause sensitivity.

Step 2 - Wait 60 Minutes

During this time, your skin should return to its natural state, the characteristics of which will determine your skin type. Do not undertake any strenuous physical activity during this hour and please don’t touch your skin.

Step 3 - Blot the Skin

Dab your face with a white tissue. Pay attention to the 'T-zone'--the area of your forehead, nose and chin. Examine the tissue for any oily residue after dabbing each area. If you have oily skin you will see this:

Step 4 - Examine the Skin 

Position a section of skin on the back of your hand between you index finger and thumb. Press the fingers towards each other. Does your skin look like this?  Using this technique exaggerates the dehydration, but allows you to identify any signs of dehydration on the facial area. 



Typical appearance of dehydrated skin. 

*The best advice it to add a gel or water based serum to the skincare routine and follow with a suitable day cream to prevent moisture loss from the skin.



Or do you notice scaly, white flakes like this?

This means the skin lacks oil and it is classified as dry.


Is the skin elastic?

The more elastic the skin, the quicker the pinched skin returns to its natural position. A skin which does not have great elasticity, not only ages prematurely, but also scars easily and tends to heal slowly. 




Knowledge Basket: Skin Type  refers to a collection of characteristics which make up a specific skin class or category. Below, we have listed the basic Skin Types. Click here to read about more complex skin types.

Step 5 - Record your findings

  • Normal skin
    • The only truly normal skin is found on new born babies.
    • All skin types have special conditions which are not considered normal
      • e.g. dehydration, sensitivity, pigmentation, ageing etc.)
  • Free Radicals are produced naturally by our bodies, the sun and the environment around us.
  • Normal skin also requires protection from free-radicals (ageing toxins).
  • Texture and tone feels smooth and supple
  • No visible oil, pores, redness or flaking.
  • Oily skin
    • Greasy residue on the tissue when blotting.
    • Large pores and visible shiny complexion.
    • Often has comedones (blackheads) and breakouts
    • Can be as a result of dehydration (lack of water in the skin)
  • Dry skin
    • May feel taut or show flakes of dead skin.
    • Small pores, hardly visible if at all
    • Prone to formation of fine lines & wrinkles
    • Moisturizing & Hydration is important for this skin type.
  • Combination skin
    •  The most common Skin Type.
    • Exhibits traits of all three of the above skin types.
    • Usually, the skin is oily in the T-zone and normal to dry elsewhere
      • Variations may occur.

Step 6 - Make Recommendations

Once you have identified the skin type or the presence of special conditions on the skin it is your duty as a Skin Expert to give the candidate advice in order for the skin to receive the best treatment and to get the desired results. 

Recommendations begin with an informative approach, as this builds trust with the receiver;  You can advise in your area of expertise and refer to a medical practitioner for other areas. You may question and make suggestions, but you may never diagnose a disease or disorder unless you are a Medical Professional.

The difference between diagnosing and assessing is demonstrated by how you communicate your observations to the candidate.

Here's an example:

Mrs Jones has a breakout on her chin. You can see it and it meets all the characteristics of Acne. There are inflamed nodules, blackheads and pustules. 

Correct response: Mrs Jones, you have a severe breakout on your chin and the area is Acne-prone. I recommend that you use  Clearogen for 60 days to stop the breakout cycle and I would like to refer you to your Doctor, he can advise you regarding additional support options, such as antibiotics. This may help to bring the Acne-prone area  under control. We need to get the bacteria under control or else it may result in scarring. 

Incorrect response: Mrs Jones, you have severe Acne on your chin. (Diagnosis) I recommend using Clearogen for 60 days to stop the Acne cycle. Your doctor will give you antibiotics to support your results.

Where did the consultant go wrong with the incorrect response?

  • A diagnosis was made.
    • A Skin Expert may identify the signs of Acne. 
    • The Skin Expert may not tell the client that they have Acne, this would be diagnosing
    • The Skin Expert may refer to Acne-prone skin, but may not diagnose.
  • A prescription was made on behalf of a doctor
    • A Skin Expert may suggest that antibiotics could be required for control
    • The Skin Expert must indicate that the candidate should discuss this with her doctor
  • Insufficient information was provided.
    • There was no motivation as to why suggestions were made.

Legal Matters

Even though Clearogen stops the formation of skin eruptions at the source, we cannot claim to cure Acne, unless the product is registered with the Medical Control Council in South Africa, in which case you would need to be a Doctor or work with a Doctor to prescribe Clearogen. This registration process would also make Clearogen far more expensive and we would lose our competitive price range. 

1.9  Extractions for Acne-prone Skin

  1. Extractions should be performed by trained professionals, but if extractions must be performed, glove-up or use tissues. 
  • Extractions are best done on a warm skin.
  • The skin must be prepared thoroughly (Cleansed and toned)
  • Pre-heat the skin with a hot towel or perform the extractions directly after a warm shower. 
    • In a professional environment, a  liquid enzyme or facial steamer will be used to;
      • soften sebaceous plugs before extractions;
      • soften superficial skin cells and to;
      • dilate pores for easy extraction of congestion.
    • Take caution when using a steam basin.
      • Placing the face too close to hot water may cause sensitivity or burn the skin 
  • When performing extractions:
    • ensure that the mouth of the follicle is opened using a sterile needle.
    • Using a lancet is the preferred method
    • This relieves pressure and ensures that the congestion moves up an out of the skin
  • Never squeeze a sebaceous cyst (blind pimple):
    • The wall of the follicle may rupture;
      • causing the infection to spread to surrounding tissue. 
  • If you have a painful swollen bump on your skin, use ice to reduce the inflammation:
    • A few blocks of ice in a jiffy bag will do the trick!
    • Hold the ice on the swollen area on and off over a period of 10 minutes
    • Once you feel less pain and swelling - tone the area and apply your Daily Lotion.

1.10 Ok -got it! Let's take the test.

The Epidermis has 7 layers

  • False, it has 5 layers
  • True

Which of the following case studies may require additional medical prescription such as antibiotics ?

Click to select the correct answer.

There are 3 main layers of the skin

  • False
  • True

The Epidermis is the top layer of the skin

  • True
  • False

The Dermis is where the sebaceous glands are located

  • True
  • False

The Enzyme 5aR causes an Oestrogen surge in the skin, which leads to DHT

  • False
  • True

Clearogen addresses the enzyme 5aR by using a testosterone inhibitor derived from Saw Palmetto

  • True
  • False

Clearogen is safe to use during pregnancy

  • True
  • False

Sebum is an other name for perspiration

  • False
  • True

Cortisol is a medication that can be applied to the skin to reduce inflammation

  • False
  • True

Cortisol is a hormone which is released by the body. It reduces inflammation

  • True
  • False

When the androgen hormone DHT attaches to the ___________________receptors, it results in the stimulation of the oil secretion, which mixes with debris and a sebaceous plug is formed.

  • sebaceous gland
  • melanocyte

The #1 cause of congestion in the skin is excess oil, which is also called ____________.

Complete the statement with the correct word.

  • Sebum
  • Serum

Skin oil is produced by the ________________ attached to the hair follicle .

  • sebaceous gland
  • seborrheic corpuscle

The hormone _______ causes a cascade of events which leads to congestion in the skin and often progresses to Acne.

  • DHT
  • DNA

If the pore remains ________ on the surface of the skin, the top layer of the plug darkens through ____________ and a blackhead is formed.

  • answer 1: open; answer 2: oxidation
  • answer 1: closed; answer 2: mitosis

DHT is produced when the ______________ based enzyme 5aR interacts with, the hormone testosterone , which is produced at the site of the sebaceous gland.

  • antigen
  • androgen

If the plug is situated lower down the opening of the skin and if the mouth of the opening is _____________ dead skin cells, this may lead to the formation of a sebaceous cyst.

  • lined with
  • closed by

Pustules ( commonly called a pimples) and other infected skin lesions are otherwise classified as ________.

  • Acne or Acne-prone skin
  • Dermatitis

Vitamin C (ascorbic acid) has anti-oxidant properties and helps with ____________________ as well as boosting the immune system, which in turn helps to prevent and heal Acne lesions.

  • wound healing
  • circulation

__________is widely known to boost the skin's immune system and is a key supplement to support skin prone to Acne.

  • Zinc
  • Caffeine

Derivatives of vitamin A called _____________, are used to treat Acne and other skin disorders.

  • retinoids
  • rhizomes

The retinoids, ___________ (Retin-A) and ____________ (accutane) are often prescribed to treat Acne. These medications may have strong side effects so they should be taken with caution and only under a doctor’s supervision.

  • Answer 1: Papaine and Answer 2: Bromaline
  • Answer 1: tretinoin and Answer 2: Isotretinoin

Most fruits and vegetables are sources of _____________ of which the highest values are found in papaya, raw red bell pepper, strawberries, oranges, broccoli, cantaloupe, lemon juice, kiwi, cauliflower, and kale.

  • Vitamin C
  • Vitamin K

Understanding Problem Skin - Section 4

  • It has been called the “beauty vitamin” because of its ability to regulate retinol levels for skin health as well as protect skin from ageing caused by oxidative stress.
    Vitamin E
  • An essential mineral, present in the body in trace amounts. A deficiency of this mineral is linked to some cases of Acne.
  • Omega-3 is from this group, which offers great value in supporting Acne-prone skin. There is strong evidence that diets high in dietary omega-3 can reduce or eliminate Acne flare-ups due to its anti-inflammatory properties in the body
    Essential Fatty Acids
  • Associated with reducing inflammation. This supplement also plays a role in hormone balance, another contributor to Acne. Its absorption may be reduced when taking zinc supplements, but it is absorbed better when taken with vitamin C.
  • Intake should be at least 8 glasses per day
  • May aggravate the skin
    stimulants, preservatives, addatives, wheat and dairy

It has been called the “beauty vitamin” because of its ability to regulate retinol levels for skin health as well as protect skin from ageing caused by oxidative stress.

Match the description to the best suited answer below.

  • Vitamin E
  • Vitamin C

It works in combination with vitamin E to reduce inflammation and boost the body’s immune system. Also linked to thyroid function.

Match the description to the correct answer below:

  • Selenium
  • Sodium

Omega-3 is from this group, which offers great value in supporting Acne-prone skin.

  • Essential Fatty Acids
  • Amino Acids

Look for ingredients that support the function of the cleanser and the overall objective of dissolving redundant skin cells and pore clogging matter.

  • Anti-blemish Toner
  • Daily Lotion

Its absorption may be reduced when taking zinc supplements, but it is absorbed better when taken with vitamin C.

  • Magnesium
  • Manganese

May aggravate the skin:

Match the description to the correct answer below. 

  • Nutrition, lifestyle, stress levels, hormone imbalance and medication.
  • Genetics

Look for Ingredients with exfoliating and anti-inflammatory properties, specifically ingredients which do not cause sensitivity on the skin or strip the skin of natural moisture.

Match the description with the correct answer.

  • Anti-blemish Cleanser
  • Facial Exfoliator

This product contains anti-bacterial properties, without the side effect of clogging pores.

  • Anti-Blemish Daily Lotion, with 3% Sulphur
  • Daily Moisturiser with Lanolin and tea tree oil

Must be applied daily and should contain Zinc Oxide , free of chemical ingredients.

Match the description to the correct answer below.

  • SPF 30 or higher
  • Lip & Eye Products


The Science of Clearogen

2.1 The Dr & Research behind the brand

Alex Khadavi, MD
Board Certified Dermatologist
creator of Clearogen

“I developed Clearogen after becoming frustrated with existing acne treatments that only addressed the symptoms of breakouts rather than its root cause, DHT”.

  • A three-step, non-invasive product
  • Encapsulated botanic ingredients ensure maximum delivery and potency of ingredients
  • Clearogen's unique formulation inhibits the production of the acne causing hormone, DHT
  • The treatment system effectively clears existing spots and prevents future breakouts.
  • Clearogen is the only skincare product that address the root cause of breakouts.
  • South African CTFA (Cosmetics, Toiletries, Fragrance Association) certified.
  • FDA-Approved & Safe for use during pregnancy
  • We are proud to lead the way in providing an innovative , effective solution to problem skin

Knowledge Basket: 

Download Clinical Data & Reports:



Clearogen is a global product available in over 40 countries

and is now available in South Africa for the first time!

The search for clear skin ends here.

2.2 What makes Clearogen unique?

There is one very profound thing that separates Clearogen from other anti-blemish skincare ranges.
Clearogen targets the root cause of Skin Eruptions, by inhibiting the production of DHT.

Knowledge Basket: Watch Video - How Clearogen STOPS DHT

2.3 Ingredient selection and formulation


  1. Micro-Encapsulated Sulphur kills bacteria while Salicylic Acid exfoliates skin. The active ingredients have a time release delivery system, increasing efficacy and decreasing sensitivity because skin is not impacted by the ingredients all at once, hence "time released".
  2. Essential Fatty Acids are able to penetrate the congestion and pores quickly, delivering the active ingredients through the cell membrane of the sebaceous gland. These ingredients inhibit the conversion of Testosterone to DHT and block androgen receptors from DHT which regulate oil production. 
  3. Most conventional anti-blemish treatments contain Benzoyl Peroxide or Sulphur and Salicylic Acid. These ingredients kill bacteria and help to unclog pores, but while this is great for targeting the symptoms of breakouts and problem skin, this approach does not address the root cause.
  4. Clearogen Targets the source of breakouts with the use of unique ingredients such as, Linoleic Acid (Essential Fatty acid), Beta-Sitosterol (phytosterol), and Green Tea Catechins. 
  5. Dodecyl Gallate Function: Anti-oxidant and preservative derived from plant tannins, used to preserve cosmetics and works as an anti-bacterial an anti-fungal agent. The skin may demonstrate sensitivity to this ingredient and it needs to be introduced systematically,if prone to sensitivity, the client should treat the occurring spots by applying toner on a q-tip (earbud) and spot treat the breakout directly on the affected area rather than toning the entire surface of the skin with cotton pads.

  6. Octyl Gallate. Function: Anti-oxidant and preservative derived from plant tannins and interestingly also found in penutbutter. In addition, this ingredient serves as an anti-bacterial and anti-fungal agent.

  7. Salicylic Acid: If the user knows that they are prone to allergies or if the user is sensitive to Aspirin, we suggest they only use the toner on q-tips directly on the acne pustules. Did you know that Salicylic Acid is Aspirin’s parent compound? (Their basic chemistry is similar). Clients who are therefore sensitive or allergic to aspirin may demonstrate sensitivity to salicylic acid too.

  8. Sulphur: Clearogen  Anti-Blemish Lotion uses natural mineral sulphur to kill bacteria and clear the skin.  Sulphur oxidises slowly to sulphurous acid in the presence of water (this includes moisture on the skin). Sulphites have an anti-bacterial and seborrheic (oil) reducing effect. Sulphur formulations are effective as micro-exfoliants and demonstrate mild antiseptic properties. Sulphur is hydrophilic, enabling dermal penetration to promote collagen and protein synthesis while reducing bacterial activity associated with breakouts.

    ​Sulphur reduces the proliferation (growth) of the P. Acnes and in conjunction with the exfoliating properties of Salicylic Acid the Sulphuric formula is able to reach the sebaceous pores and the keratogenous zone for metabolic and catabolic availability. The mild oxidative properties of topical sulphur helps to restore a normal pH. Sulphur is one of five ingredients that are approved by the FDA (Food & Drug Association of America), to treat seborrheic dermatitis. Biologic formulations of sulphur enable penetration to dermal layers to optimise micro-exfoliation. Yeast is normally present in sebaceous skin and the mild oxidative effects of sulphur neutralise the effects of this yeast in the skin.

Knowledge Basket: Propionibacerium Acnes is a natural  inhabitant of sebaceous follicles and a healthy population is maintained by cysteine (a sulphur-containing amino acid which occurs in keratins and other proteins and is a constituent of many enzymes).  Abnormal accumulation of P.Acnes alters the skin’s pH, resulting in follicular infection and breakouts. 

Key  Ingredients







The primary sources of Essential Fatty Acids include;  Gamma Linolenic acid (GLA), Alpha Linolenic acid (ALA), Linoleic Acid, Oleic Acid and Saw Palmetto Extract. 


These essential fatty acids are found in plant oils and are the most powerful inhibitors of 5-Alpha Reductase known today.  They inhibit Type I and II of the 5-AlphaReductase, which leads to the formation of DHT. Additionally, GLA, ALA and Oleic Acid have potent anti-inflammatory properties helping to reduce redness in the skin.






Sulphur shares many of the same acne-fighting properties as Benzoyl Peroxide, such as reducing bacteria growth and regulating oil production. However, it is also a great alternative for sufferers with sensitive skin who are seeking a gentler treatment for problem skin.

Salicylic acid is a keratolytic, comedolytic and bacteriostatic agent, causing the cells of the epidermis to shed more readily. This opens clogged pores and neutralises bacteria within, preventing pores from clogging up again. Salicylic acid is also largely known for its anti-inflammatory properties. 



Saw Palmetto extract which is a known anti-androgen is the liposerolic extract of the fruit of Saw Palmetto. Saw Palmetto has shown to effectively block DHT and is also believed to stop the androgen receptors which are found on the sebaceous glands.

Beta-Sitosterol a plant sterol derived from Saw Palmetto,
which supports the skin’s immune system, conditions the skin and reduces the formation of DHT. 


Green Tea Catechins

 work as anti-oxidant and anti-inflammatory agents, promoting healthier skin.

2.4 Who should use Clearogen?

Adults            (Ages 20+)

Adults can be prone to Acne for a number of reasons including hormonal fluctuations, medication, lifestyle choices, stress factors and genetics. Some adults continue to get breakouts well into their 30s, 40s, 50s and beyond . It is possible to get acne for the first time as an adult and Dermatologists call this “adult-onset acne.”  In some cases Rosacea may be misdiagnosed as Adult Onset Acne, it is therefore best to undergo a medical examination when unsure. 

Teenagers    (Ages 13 - 19)

When hormones start to surge in the body during puberty, about 90% of teenagers begin to develop breakouts and skin problems. Testosterone is one of the main hormones involved in puberty, in both sexes, and its conversion to DHT is linked directly to a Skin Eruptions and Breakouts. Excessive oil production within the pores of the skin is caused by high levels of DHT from elevated testosterone levels. This excessive oil leads to clogging of the pores and comedones, which, in turn, lead to papules, pustules, nodules and eventually, cysts.

Reducing DHT is the most important step in treating adolescent breakouts and supporting Acne-prone skin. Traditionally, anti-blemish treatments decongest the pores and control the bacteria, but do nothing to address DHT, which is the underlying cause of blemishes. Cleorogen is the first product on the market to focus on the root cause of blemishes, Clearogen lowers DHT production to normalise the skin’s oil production, clears existing blemishes and fights future breakouts.

If left untreated, teenage skin prone to Acne can be left with permanent scarring. It’s extremely important to use a comprehensive treatment as soon as signs appear. Clearogen is proven safe and effective in treating blemishes for teenagers. It gently clears the existing breakout and helps prevent future breakouts.

Pre-Teens     (Ages 8 - 12)

Studies show that the earlier Acne appears the more likely it is to be severe. Acne-prone skin is a reality for 8 in 10 Pre-Teens. Sadly, our modern diet which includes genetic modification of food sources has proven to adversely affect the developing hormonal system (endocrine system) of Pre-Teens and Teenagers alike. Added to this, poor dietary choices such as take-away food and high sugar treats add to the problem. While co-operation is required to educate Pre-Teens about healthy meal choices, a number of other factors weigh in on stimulation of early hormonal development.

Recent studies confirm that BPA Plastic Replacements, Plastics and Polystrene (Also called styrofoam) contain hormone altering chemicals, which may contribute to premature development in Pre-teens. Makes one think twice about that take-away coffee - free cortisol jolt from the caffeine  and a dose of hormone disruptors from the cup.

Genetics play a large role in the production of testosterone and therefore the presence of DHT which is the #1 cause of Acne. Pre-Teens are also far more competitive than in years passed, as pressure mounts to groom top academic or sport personalities from a young age, with schedules pack, there's no time left to play.

While Clearogen is an excellent topical treatment to reduce the effects in Pre-Teens susceptible to Acne-prone skin, every effort should be made to avoid hormone disruption prompted by poor lifestyle choices.

Skin Lesions

  • Comedone (Blackheads) 

  • The comedone is a basic blemish, which is essentially a blocked pore.
    • The clogged pore is caused when the mouth or opening of the pore is covered by surface cells.
    • This is called a closed comedone and forms a white bump under the skin
    • Closed comedones are also know as "Asphixiated Skin" and are most common in oily skin types
    • Asphyxiated skin is the type of skin that  has a complete obstruction in the pilosebaceous duct.
      • This can be due to lack of blood circulation or 
      • the application of improper astringent cosmetics which upset the natural pH balance
      • Asphyxiated skin most commonly occurs in cases where "oily skin" is present.
      • The Sebum is not effectively expelled to the surface and it solidifies within the pore
    • Blackheads open comedones, which are not covered by surface cells.
    • Blackheads appear blackish on the surface of the skin, hence the name.
    • This black colour is not due to dirt, but due to the reaction of oxygen with the excess oil.
  • Millia (Whiteheads)

    • These occur for a number of reasons such as
      • Dehydration
      • Medical Conditions such as cholesterol - usually visible around the eye area.
      • Lipids that solidify in the skin
        • There are 3 main lipids in the skin: Essential Fatty Acids, Ceremides & Cholesterol
        • If there is a lack of hydration in the skin, the lipids solidify and form "Whiteheads" 
  • Papules

    • These red bumps on the skin, occur when comedone becomes inflamed.

      • Papules can be tender, but usually do not contain pus unless they become infected.
  • Pustules or pimples

    • Problem skin lesions that contain pus and are red at the base.

  • Nodules

    • These are more serious testosterone skin lesions.
    • They lodge deeper in the skin, are painful, and can cause scarring.
  • Cysts

    •  Like nodules, these lesions form deep inside the skin
    • painful, filled with pus and can cause scarring

2.5 When should use be discontinued?

  • Medical Contra-Indications
    • i.e. when a doctor advises that the user should discontinue use
  • Restricted Use:
    • Environmentally exposed skin (Sportsmen & Women) e.g. swimmers
    • Avoid the delicate eye and lip area


  • Avoid using Clearogen when:
    • Dyness, sensitivity or redness is present. 
    • If persistent itching or excessive flaking is present.

Specialised Conditions:

  • Rosacea 

    ​This condition is characterised  by chronic facial rednesssmall and superficial dilated blood vessels on facial skin, papulespustules, and swelling

    (say "roh-ZAY-shuh")

    This a very common skin condition that usually affects people over the age of 30. It causes redness on the nose, cheeks, chin, and forehead. Some people get little bumps and pimples on the red parts of their faces. Rosacea can also cause burning and sensitivity of the eyes. Essentially is thought that Rosacea is brought on by systemic stress or as an immune response of the skin to allergens. It would be easy to mistake Rosacea for a breakout is you are not aware of this condition. Should you suspect that your client may symptoms linked to Rosacea refer them to a medical professional in a discrete way.


    NB: Never diagnose a client unless you are a Medical Professional. As therapists and consultants we may advise clients to take precautionary steps and encourage them to see a Medical Expert. 

  • Sunburn

  • Clearogen 

2.6 User Guide (Reference Chart)

Download  the User Guide Chart 
Download the Clearogen Product Summary


  • Wet hands and pat facial area to dampen the skin
  • Apply one pump of Clearogen Anti-Blemish Cleanser in the palm of the hands
  • Dab hands together and apply to skin in a patting motion
    • Cover the main areas of the face, avoiding the eye and lip area.
  • Using the fingertips, start working in a circular motion from the neck upwards and over the jaw line, to the cheeks and over the nose and upper lip. Work up to the temples and ending with the forehead. Avoid cleansing over the eye and lip area completely. The cleanser contains salicylic acid which may have a drying effect on these delicate areas.
  • Rinse the skin thoroughly with lukewarm water and pat dry, do not rub or pull the skin.
  • The client should use cotton pads to tone the skin.
  • Do not dampen the cotton pads with water as this will dilute the toner.
  • If the client has sensitive skin, she may dampen the cotton pads before soaking them in toner.
  • The cotton pads must be pressed between palms to remove excess water
  • Add a few drops of toner to the cotton pads.
  • Wipe the skin in an upward stroking motion.
  • The client may observe yellow-brown particles or a greyish residue on the cotton pads.
    • This is an indication of dead skin cells and oil.
    • The active toner removes dead skin cells and unclogs pores to reduce breakouts.
  • Directly after cleansing and toning, apply The Anti-Blemish Daily Lotion (step 3) can be applied to the problem area only or the entire face, depending on skin type and sensitivity.
  • Always exclude the eye and lip area when using the cleanser and toner.
    •  nourishing, protective products should be used on the eye and lip area.
  • The client should be advised to avoid friction on the facial skin and muscles 
  • When performing a skincare routine,
    • Gentle upward and outward motions are essential to prevent stretching the delicate tissue


Blind Pimple: Professionals call this a sebaceous cyst. These are like pimples, but they form deep inside the skin instead of on the surface. Often there is no visible yellow head, as the pus is trapped deep inside the follicle or pore:

Quick Fix: Alternating heat and cold on the area will cause the infection to surface and can then be drained professionally. The temperature alternation will also greatly reduce swelling and increase blood supply to the area to aid healing.

How to do it:  Keep a frozen cup of water in the freezer (Polystyrene Cups work best). The cup will protect your hands from the cold. After cleansing your skin, before applying toner, ice the affected area by holding the ice over the affected area. You should not keep the cup still, but should use a circular motion to avoid cooling the area too much. When your skin starts to feel numb, take a teaspoon of pure paprika and mix with an equal part of water to form a paste. Using an earbud apply a tiny bit of paste on the exact spot (cyst).

Do not apply the past over the whole skin as it will burn like crazy and irritate the rest of the skin. If you don’t have Paprika, Cinnamon or Ginger Essential oils work well too.

You will need to dilute the Essential oil with olive oil (Equal parts, so one drop olive oil for every drop of essential oil) to prevent burning the skin. Spice oils generate heat on the skin. Rinse the area and ice one last time. Now proceed with toning and apply the anti-blemish Day Cream. The science behind this spot reduction treatment lies in the vasodilation and constriction of capillaries, which allows waste product to be removed though the lymphatic system of the skin. 

2.7 Competitor Analysis (Easy to use reference chart)

2.8 Helpful to know


The skin is the body’s outer most visible protective layer and it is often a reflection of one’s general hygiene and health. Apart from controlling your DHT levels through the use of Clearogen’s easy three step skin care solution, there are nine skin problem prevention tips provided by Clearogen to ensure that your skin remains constantly beautiful, smooth and clear – and that your self-esteem and confidence levels remain intact.

It is important to remember that genetics play a significant factor in your body’s predisposition to problem skin, and your family history is indicative of the nature of your DHT production levels. In short, if one or both of your parents suffered from severe skin problems, you are more likely to suffer from moderate to severe problem skin as well. Therefore, if you are aware that skin problems do run within the family genes, early detection and prevention of problem skin is of essence, begin to make use of a skin care solution – Clearogen –at the first signs of skin problems in order to keep DHT in check before it takes root.

  1. While acne is not necessarily formed by unhealthy diets, it can act as an aggressor or contributing factor to skin problems. The trick is not to avoid your favorite foods but rather, through trial and error, to find what kinds of food work or do not work for your skin type. For example, if certain foods, such as greasy chips or chocolates, cause you to break out the following day, simply try to avoid them as best you can. In addition to this, drinking plenty of water a day is of crucially important to cleanse the body and the system of any toxins when eating foods that may act as reactants to causing pimples and embarrassing blemishes. 
  2. If you are a sun baby and are cautious of your skins health by making use of sunscreen, always try to purchase oil-free sunscreen with a sun protection factor (SPF) of 30 or higher that says "broad-spectrum" on the label, which means it protects against ultraviolet A (UVA) and ultraviolet B (UVB) rays. Actively search for products labelled "non-comedogenic," which means that it will not clog your pores – which is essential when trying to avoid acne and skin problems.
  3. Both males and females should avoid using greasy hair products as they can clog your pores when your hair brushes and falls against the surface of your face. Additionally, make an attempt to cover your face when applying or spraying gels or foams directly onto your hair and if you are prone to oily hair, it is recommended that you shampoo with a non-oily product daily.
  4. Hair contains oils that, when rubbed off on the surface of the skin can block pores and cause unwanted sulfate – even if you do not make of gel and spray hair products. Therefore, when you are able to do so, try to keep your hair out of your face or from falling in your face unnecessarily. Also, pull your hair back when you sleep so that it does not pointlessly rub against your face and clog your pores.
  5. Avoid using heavy cosmetics and plastering your face with makeup. Try to find cosmetics that are low in oil levels or even better that are oil-free. Heavy makeup and oily cosmetics very quickly and easily clog your pores with dirt and oil, preventing your skin from breathing freely and cleanly, which can lead to the formation of nasty, unwanted pimples. A simple way to tell if cosmetics are either high or low in oil levels is to determine how creamy the foundation or blush may be. Creamy foundation or blushes generally clog your pores while mineral-based cosmetics, which are light and powdery, are less likely to do so. In addition to this, it is of extreme importance that you never, ever go to bed with makeup on, no matter how tired you may be. Always make a trip to the bathroom and wash your face of all makeup so that your skin is rid of the makeup blockage and dirt infestations, freeing your pores and allowing them to rejuvenate during the night after a cleansing wash.
  6. It is imperative that you keep your makeup applicators clean. Don’t reuse an old makeup sponge rather wash or replace it so that you avoid rubbing old dirty oils onto your clean skin. If you wash your face using your hands, wash them first and only use your fingertips. Also, always clean your skin before you apply makeup so that you don’t apply more pore clogging substances over dirt already there.
  7. A tip that probably comes as a shock - is to regularly clean your cell phone and handbag. Your cell phones are touched and breathed into on a constant basis, implying that all that dirt gets transferred onto your skin when holding the handset against your face. Therefore you need to clean your handsets with a disinfectant wipe often to avoid hand to cheek bacteria which will aggravate your skin. Handbags and purses pick up plenty of bacteria when placed on counters, floors and almost any surface, so give them a wipe every so often to avoid hand to face contamination.
  8. A healthy lifestyle is crucial in combating all ranges of skin problems and even more so if a person suffers from Acne-prone skin or if the problem is hereditary.  If Clearogen is your preferred skin care solution, and the above mentioned tips are adhered to regularly, the results of your skin will inevitably speak for themselves.  For personal advice on using Clearogen for your unique skin problems please get in touch with us at
  • A 20 minute walk per day will help increase circulation and promote wellbeing. 
  • Drink at least 8 x 250 ml glasses of water per day.
  • Your skin only receives the benefit of the 8th  glass of water.
    • The body uses the rest of the fluids for cellular communication and waste removal.
  • When it comes to Fruit and Veg, eat the rainbow!
    • Your skin needs the vitamins and minerals for repair and maintenance.
    • Eat a variety of nuts, seeds (pumpkin, linseed, flaxseed etc.), avocado’s, fish and olives
      • This increases the ease your Essential Fatty Acid  levels in the body
      • EFA's promote healing and have an anti-inflammatory action
  • Avoid excessive animal fat or fried foods as these may affect the consistency of the skin oil.
    • To avoid congestion, make every effort to keep the sebum (oil) as fluid as possible.
    • Berries such as strawberries, blueberries and similar types are high in Vitamin C.
      • This is the only vitamin that encourages production of new cells in the body.
      • Taking  high quality vitamin c  may also enhance your clear skin results.
  • Taking supplements, 
    • Ask your Skin Expert about additional supplements which may boost results
      • These include,but are not limited to Zinc (Immunity), Selenium & Magnesium
  • Excessive sugar consumption may aggravate the skin.
  • Sugar can be consumed in many hidden forms;
    • e.g. alcohol, iced tea, refined foods and almost all low fat or fat free foods.
  • Excessive caffeine intake may cause increased adrenal activity, which could aggravate breakouts.
  • Preservatives and colorants may contribute to thickening of skin oil (sebum)
  • Sensitivity to wheat (gluten), yeast, eggs and dairy could also surface as breakouts on the skin.
  • Alkalising the body will prove beneficial to improving the complexion.  
    • (Avoid highly processed foods and drink lemon juice in warm water daily).
    • This may also be helpful if battling with bladder infections.
  • Avoid fizzy drinks and artificial sweeteners.
  • 1 cup of Green Tea per day contains 10 time the potency of Vitamin E in anti-oxidants,
    • Green Tea helps to heal and repair the skin and body.
  • A sluggish digestive system may result in breakouts on the skin, as waste product accumulates in the body. A healthy bowel movement is 1 to 2 times daily.
  • Do a parasite cleanse every 6 months. Information on this process is available from your local Health Shop or Pharmacy. The toxins released from parasites may aggravate breakouts or even be causing them. Parasites can range from relatively common Candida to more pesky organisms. 
  • Lack of sleep generally affects the repair processes and general balance of the body

2.9 Troubleshooting

Every skin type is unique and you need to be prepared for a range of scenarios which may occur:

Allergic Dermatitis

Signs of intolerance to ingredients:


  • Redness
  • Swelling
  • Itching
  • Excessive Flaking
  • Sensitivity
  • Inflamed bumps

Sensitivity Test

If an allergy is suspected, the client should perform a sensitivity test on the inner fold of the elbow. 

  1. Apply Cleanser, toner and cream on 3 separate areas. Use a cosmetic pencil to indicate which product is applied to which area.
  2. Wait 20 minutes to see if redness appears.
  3. The picture below indicates sensitivity to the product applied. 




Impatient Client:

This  client  wants to see results in an unrealistic time frame.


Reassure the client that the result will come, provided that the 60 Day routine is adhered to without fail.

Give DHT Explanation and highlight the fact that the cells take a minimum of 28 days to respond to treatment.

Demonstrating knowledge, builds trust with the client and they will feel reassured by your ability to understand what they are going through.


Remember that different grades of Acne-prone Skin respond within different time frames. 


Mild Breakout 
 2 to 4 weeks.

Moderate Breakout 
 4 to 6 weeks.

Severe Breakout 

6 to 8 weeks

Cystic Breakouts:
8 to 24 weeks.


Setting realistic expectations with achievable benchmarks will reduce the likelihood of users feeling disappointed. 


The client has a relapse and feels frustrated with the lack of progress. i.e. not seeing 100% improvement after 60 days.


Explain to the user that due to hormonal fluctuations he/she may be experiencing a flare-up and that sometimes the results take a little longer, but results will come.


You may advise the user that answering a sequence of lifestyle based questions will

help you to determine which outside  influences might be contributing to the  breakout or slow progress.


Clearogen offers 95% improvement in 60 days or less + ongoing control and gradual improvement. This is not a quick fix, it is a long term solution.


Some Acne-prone skin types do not respond to topical treatment alone.  


If Cystic conditions and severe breakouts persist after the 60 day mark, it is wise to consider adding antibiotics to the routine, as stubborn bacteria may be hampering the recovery of the skin long after DHT levels are under control. 

This is usually a 6 to 8 week course of antibiotics, prescribed by a Doctor and it is a good idea to recommend the use of a probiotic when treating with antibiotics. 


Dryness, Redness or Sensitivity


By the time you are aware of this issue,the user is already experiencing mild to severe discomfort. 

Determine when the symptoms started to show
Be compassionate, but quickly bring the users attention to how the situation can be improved. 


Possible causes may include : 

 incorrect use of the toner i.e.  applying the toner on sensitive, dry skin, may result in an inflammatory reaction. 

Additionally applying the toner over the delicate eye and lip area,  may result in peeling, flaking or sensitivity. 

Exceeding recommended use of the toner during week 1 i.e. The toner should be used once per day during week 1.

Using the toner on Skin Types that are not suited to the product. Please refer to the User Guide Chart  for more detail.

In rare cases it may be an intolerance to ingredients. Use the Sensitivity Test to determine if this is the case.


Find the optimal toner dosage per problem area.

Apply with cotton pads, either once or twice per day.

Only apply to the affected area or Acne-prone skin.  


2.10 Ok. Got it! Let's take the test

Clearogen was developed by ;

  • Dr Alex Khadavi, a board certified dermatologist in the USA
  • Dr Alex Khadavi, a board certified dermatologist in the USA

Clearogen is the only topical aniti-DHT Skincare Range on the market today.

  • False
  • True

Clearogen offers users 3 easy steps to clear skin.

  • True
  • False

Clearogen's Anti-blemish toner must always be used twice per day on the whole face.

  • False, Use once per day during the first week, or if there is any sign of sensitivity avoid the area.
  • True, this will give the best results.

Clearogen's Daily Lotion contains powerful 5aR inhibitors.

  • False
  • True

5-alpha reductase is the enzyme that triggers DHT production, resulting in excess oil.

  • True
  • False

Propionibacterium is found in dairy products and in the skin.

  • True
  • False

Propioniacterium is also called P. Acnes and is more prolific on Acne-prone skin.

  • False
  • True

Clearogen's anti-blemish cleanser contains

  • salicylic acid and botanic ingredients, which are anti-inflammatory, purifying and healing
  • Antibiotics to kill bacteria

Clearogen's Anti-blemish Toner contains 1% Salicylic Acid

  • to add additional exfoliating properties to the routine and botanic extracts to aid deeper purification of the skin.
  • , because the cleanser only contains soothing ingredients.

Clearogen's Daily Lotion contains 3% Micro-encapsulated Sulphur,

  • which penetrates into the skin on a time release system to ensure optimal absorption of active ingredients.
  • which is derived from smaller Sulphur crystals.

The hormone levels of the skin take approximately 28 days to respond,

  • even after results are visible and therefore Clearogen must be used for 60 consecutive days as a minimum.
  • except in cases of Cystic breakouts, where the skin responds quicker.

Clearogen must be used consecutively and 1 kit should last

  • 4 months
  • 2 months

Clearogen's Dailly Lotion contain a Sulphur compound (powder), giving the lotion a granular texture.

  • Yes , but only during application. The granules soon dissolve into the skin, where the Sulphur goes to work as an antibacterial treatment.
  • No, that is incorrect. The lotion should never be granular.

Cystic Acne may take longer to respond to treatment and the addition of antibiotics may be required

  • in some cases
  • in all cases

If the user is not responding to treatment after two weeks, toner use must be increased to three times per day.

  • False, never advise the user to perform spot treatments.
  • This will cause flaking and sensitise the skin if applied to the whole face. An earbud may be used to dab spots for quicker reduction.

Using the toner twice per day during the first week

  • may result in peeling or flaking and in rare cases an immune response from suddenly introducing such high levels of active ingredients.
  • will help the skin peel quickly to clear.

The toner should be seen as a

  • liquid exfoliator - it dissolves dead skin cells. Therefore caution should be taken not to overuse.
  • gentle, second cleansing step

The botanic ingredient in the toner, which may trigger a reaction if introduced too frequently is

  • a plant tannin called, Dodecyl Gallate. This ingredient is known for its preservative, anti-bacterial and anti-fungal properties.
  • derived from grapes and is an excellent anti-oxidant.

Using the toner twice per day during the second week is,

  • not recommended
  • highly recommended, but monitor the skin for sensitivity and make adjustments. (Pre-teens, should stick to once per day).

The Clearogen Anti-blemish cleanser contains 2%

  • Salicylic acid for exfoliating and anti-bacterial properties
  • Malic acid for exfoliating and anti-bacterial properties

In addition to maintaining moisture levels in the skin, the role of Essential Fatty Acids in Clearogen formulations are to:

  • Assist penetration of active ingredients through cell membranes and to act as DHT blockers at the Sebaceous Glands.
  • to prevent Sebum from reaching the surface of the skin.

Saw Palmetto, one of the key ingredients in the Clearogen Daily Lotion, contains Beta sitosterol , a type of

  • steroid, which reduces the effects of DHT.
  • antibiotic to control bacteria

Clearogen is suitable for all age groups who battle with hormonal breakouts.

  • False
  • True

If there notable improvement is not evident in cystic breakouts after 3 weeks of Clearogen use, which treatment options can be considered under medical guidance?

  • The addition of topical or oral antibiotics, anti-androgen medications and/or Spironolacone
  • More invasive facial treatments