Topic: Aztreonam

Aztreonam is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms. 

Aztreonam is a Monobactam Antibacterial. The chemical classification of aztreonam is Monobactams.

Aztreonam is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.


1. Aztreonam

Aztreonam: Video


This is a short video presentation on the SAR and pharmacology of Aztreonam. It's best if you take some notes on the side while viewing the video.

Consider the following statements about Aztreonam coverage and indicate the correct answer.

  • Aztreonam is a broad spectrum antibiotic
  • Aztreonam is a narrow spectrum antibiotic

Which of the following is NOT susceptible to Aztreonam?

  • Listeria monocytogenes
  • E. coli
  • Klebsiella pneumoniae
  • Pseudomonas aeruginosa

Which of the following is correct about the ADME properties of Aztreonam?

  • It is not orally bioavailable and must be delivered intravenously.
  • It has excellent oral absorption.
  • It is extensively metabolized by the liver.

Click on the structure representing Aztreonam.

Identify the beta-lactam ring within Aztreonam structure [click & then submit]

Antifungal Therapy



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